![]() Our findings indicted the potential importance of assessing CRC prognosis by combining clinicopathological characteristics with platelet index. This study found that MPV is correlated with patient’s survival and is an independent risk factor for prognosis. In the present study, we investigated the effect of MPV levels on pathological parameters and clinical outcome. In a small-size sample study, MPV was found to be a prognostic indicator in metastatic colorectal cancer patients treated with bevacizumab-combined chemotherapy 14. ![]() Our previous study demonstrated that MPV was elevated in CRC 13. Altered MPV levels were found in gastric cancer, ovarian cancer, lung cancer, and breast cancer 9, 10, 11, 12. Mean platelet volume (MPV), the most commonly used measure of platelet size, is a surrogate marker of platelet activation 8. A normal platelet count could conceal the presence of highly hypercoagulative and pro-inflammatory cancer phenotypes in the presence of efficient compensatory mechanisms 7. However, platelet count is determined by the balance between the rate of production and consumption of platelets. Increased platelets are correlated with a decrease in overall survival and poorer prognosis in various types of cancer, including pancreatic cancer, gastric cancer, colorectal cancer, endometrial cancer, and ovarian cancer 2, 3, 4, 5, 6. There is emerging evidence to suggest that platelets mediate tumor cell growth, angiogenesis, and dissemination 1. Platelets play a pivotal role in cancer progression and metastasis. Therefore, identification of appropriate markers for prognosis in CRC is of great importance. Although there are many established therapeutic strategies including surgery, chemotherapy and radiotherapy, the high rate of relapse and distant metastasis still threaten a large percentage of patients. Elevated MPV might act as a marker of prognosis and therapeutic target for CRC.Ĭolorectal cancer (CRC) is the third most commonly diagnosed cancer in males and the second in females. In conclusion, MPV is easily available in routine blood test. Cox regression analysis showed that MPV was an independent prognostic factor in CRC (HR = 1.452, 95% CI = 1.118–1.884, p = 0.005). Patients with increased MPV had poor overall survival compared with those with normal level (60.0% vs. Elevated MPV was associated with tumor differentiation (p < 0.001). Of the 509 CRC patients, high MPV levels were detected in 150 (29.5%) patients. ![]() Kaplan-Meier method and Cox regression were used to evaluate the prognostic impact of MPV. The relationships between MPV and clinicopathological characteristics were analyzed. The retrospective study recruited 509 consecutive CRC patients between January 2009 and December 2009. The purpose of this study was to elucidate the predictive significance of MPV in CRC. However, the clinicopathological significance and prognostic value of MPV in colorectal cancer (CRC) is still elusive. Altered mean platelet volume (MPV) is implicated in several malignancies. ![]()
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